posted on 2015-12-18, 00:00authored byRamarao Parella, Srinivasarao Arulananda Babu
A Pd(OAc)2-catalyzed, AgOAc-promoted and bidentate ligand-directed Z selective C–H activation, followed by the β-arylation
of the C(sp2)–H bond of N-(quinolin-8-yl)acrylamide
systems with aryl- and heteroaryl iodides, and a contemporary method
for the construction of various Z-cinnamamides and
β,β-diarylated acrylamides are reported. A plausible reaction
mechanism comprising the bidentate ligand-aided, chelation-based C–H
functionalization was proposed for the observed Z selective β-arylation of N-(quinolin-8-yl)acrylamide
systems.