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Pd(II)-Catalyzed Enantioselective C–H Activation/C–O Bond Formation: Synthesis of Chiral Benzofuranones

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posted on 30.01.2013 by Xiu-Fen Cheng, Yan Li, Yi-Ming Su, Feng Yin, Jian-Yong Wang, Jie Sheng, Harit U. Vora, Xi-Sheng Wang, Jin-Quan Yu
Pd­(II)-catalyzed enantioselective C–H activation of phenylacetic acids followed by an intramolecular C–O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C–H functionalizations through Pd­(II)/Pd­(IV) redox catalysis.

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