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Pd(II)-Catalyzed Direct Sulfonylation of Benzylamines Using Sodium Sulfinates

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posted on 05.02.2019, 00:00 authored by Ujjwal Karmakar, Rajarshi Samanta
A Pd­(II)-catalyzed direct sulfonylation of benzylamines with sodium sulfinates using a removable bidentate directing group is illustrated. The transformation is highly regioselective and tolerates wide functional groups. The mechanistic study reveals that radical species are involved in this reaction. This method delivers a direct synthetic strategy to obtain highly functionalized sulfonylated benzylamines.