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Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O‑Acetals

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posted on 06.03.2015, 00:00 by Liyin Jiang, Tao Jia, Min Wang, Jian Liao, Peng Cao
Palladium-catalyzed asymmetric intermolecular hydroalkoxylation of allenes has been developed by using phenol as a pronucleophile. Acyclic O,O-acetals were obtained in high yields (up to 98%) with good to excellent enantiomeric excesses (up to 94% ee).