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Pd-Catalyzed Dehydrogenative Aryl–Aryl Bond Formation via Double C(sp2)–H Bond Activation: Efficient Synthesis of [3,4]-Fused Oxindoles

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posted on 16.01.2015, 00:00 by Ala Bunescu, Tiffany Piou, Qian Wang, Jieping Zhu
A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C­(sp2)–H functionalization steps.

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