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Pd-Catalyzed Cyclization and Carbene Migratory Insertion: New Approach to 3‑Vinylindoles and 3‑Vinylbenzofurans

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posted on 04.10.2013, 00:00 by Zhenxing Liu, Ying Xia, Shiyi Zhou, Long Wang, Yan Zhang, Jianbo Wang
A Pd-catalyzed stereoselective synthesis of 3-vinylindoles and 3-vinylbenzofurans has been developed. The reaction merges the alkyne-based Pd-catalyzed cyclization and Pd carbene migratory insertion in a single catalytic cycle, generating a C–C single bond and a CC double bond in one operation.