ol200602x_si_002.cif (19.32 kB)

Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands

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posted on 06.05.2011, 00:00 by Ziping Cao, Yilin Liu, Zhaoqun Liu, Xiangqing Feng, Minyang Zhuang, Haifeng Du
A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee’s.