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PdCl2-Catalyzed Oxidative Cycloisomerization of 3-Cyclopropylideneprop-2-en-1-ones

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posted on 01.06.2012, 00:00 by Maozhong Miao, Jian Cao, Jingjing Zhang, Xian Huang, Luling Wu
A novel PdCl2-catalyzed oxidative cycloisomerization of 3-cyclopropylideneprop-2-en-1-ones, providing a facile synthesis of highly strained functionalized 2-alkylidenecyclobutanones via furan-fused cyclobutene intermediates, is reported. An interesting route to 2(3H)-furanones with a spiro-cyclopropane unit from the obtained 2-alkylidenecyclobutanones via a ring-contraction rearrangement reaction is also realized.