jo9b03397_si_002.cif (1.96 MB)

Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of 3‑Allylidene-2(3H)‑oxindoles and 3‑Allylidene-2(3H)‑benzofuranones

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posted on 24.03.2020, 23:03 by Naziya Parveen, Govindasamy Sekar
A single-step, stereoselective protocol for the synthesis of unsymmetrically substituted (E)-3-allylideneoxindole and (E)-3-allylidenebenzofuran from readily accessible starting materials using palladium binaphthyl nanoparticles (Pd-BNPs) has been developed. Pd-BNP showing a wide range of functional group tolerance and an immense array of substrate scope have been explored with the successful synthesis of the drug molecule “tubulin polymerization inhibitor” free from trace metal impurities. The model reaction is extended to a gram-scale synthesis, and one of the products is utilized for derivatization. The Pd-BNP has been recycled up to 5 catalytic cycles without any loss in reaction yields and particle size of nanoparticles.

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