ol501048x_si_002.cif (59.98 kB)

Palladium-Catalyzed Tandem Intramolecular Oxy/Amino-Palladation/Isocyanide Insertion: Synthesis of α‑Benzofuranyl/Indolylacetamides

Download (59.98 kB)
posted on 06.06.2014, 00:00 by Nuligonda Thirupathi, Madala Hari Babu, Vikas Dwivedi, Ruchir Kant, Maddi Sridhar Reddy
A novel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/amino­phenyl)­propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/aminopalladation, isocyanide insertion, and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade, and the reactions are carried out under mild conditions to afford the products through high functional tolerance.