jo3009337_si_002.cif (16.82 kB)
Palladium-Catalyzed Double Carbonylation Using Near Stoichiometric Carbon Monoxide: Expedient Access to Substituted 13C2-Labeled Phenethylamines
dataset
posted on 2012-07-20, 00:00 authored by Dennis
U. Nielsen, Karoline Neumann, Rolf H. Taaning, Anders T. Lindhardt, Amalie Modvig, Troels SkrydstrupA novel and general approach for 13C2- and 2H-labeled phenethylamine derivatives has been developed,
based
on a highly convergent single-step assembly of the carbon skeleton.
The efficient incorporation of two carbon-13 isotopes into phenethylamines
was accomplished using a palladium-catalyzed double carbonylation
of aryl iodides with near stoichiometric carbon monoxide.
