jo3009337_si_002.cif (16.82 kB)
Palladium-Catalyzed Double Carbonylation Using Near Stoichiometric Carbon Monoxide: Expedient Access to Substituted 13C2-Labeled Phenethylamines
datasetposted on 2012-07-20, 00:00 authored by Dennis U. Nielsen, Karoline Neumann, Rolf H. Taaning, Anders T. Lindhardt, Amalie Modvig, Troels Skrydstrup
A novel and general approach for 13C2- and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.