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Palladium-Catalyzed Stereoselective Formation of Substituted Allylic Thioethers and Sulfones

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posted on 18.11.2016, 20:03 by José Enrique Gómez, Wusheng Guo, Arjan W. Kleij
A general method is reported for the stereoselective preparation of highly functionalized allylic thioethers. This protocol is based on a Pd-catalyzed thiolation of modular vinyl cyclic carbonate substrates and features high (Z)-selectivity, good yields, minimal waste, ample product scope, and operational simplicity. A one-pot strategy was used for the stereoselective formation of pharma-relevant allylic sulfones derived from their in situ prepared thioether precursors.