ol6b02981_si_003.cif (552.53 kB)
Palladium-Catalyzed Stereoselective Formation of Substituted Allylic Thioethers and Sulfones
dataset
posted on 2016-11-18, 20:03 authored by José
Enrique Gómez, Wusheng Guo, Arjan W. KleijA general method is reported for
the stereoselective preparation
of highly functionalized allylic thioethers. This protocol is based
on a Pd-catalyzed thiolation of modular vinyl cyclic carbonate substrates
and features high (Z)-selectivity, good yields, minimal
waste, ample product scope, and operational simplicity. A one-pot
strategy was used for the stereoselective formation of pharma-relevant
allylic sulfones derived from their in situ prepared thioether precursors.
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vinyl cyclic carbonate substratesselectivitySulfoneSubstituted Allylic Thioethersfunctionalized allylic thioethersstereoselective preparationsimplicitystereoselective formationproduct scopemethodPd-catalyzed thiolationthioether precursorsone-pot strategypharma-relevant allylic sulfonesPalladium-Catalyzed Stereoselective Formationyield