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Palladium-Catalyzed Ring-Closing Reaction via C–N Bond Metathesis for Rapid Construction of Saturated N‑Heterocycles

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posted on 19.10.2020, 15:25 by Bangkui Yu, Suchen Zou, Hongchi Liu, Hanmin Huang
The ring-closing reactions based on chemical bond metathesis enable the efficient construction of a wide variety of cyclic systems which receive broad interest from medicinal and organic communities. However, the analogous reaction with C–N bond metathesis as a strategic fundamental step remains an unanswered challenge. Herein, we report the design of a new fundamental metallic C–N bond metathesis reaction that enables the palladium-catalyzed ring-closing reaction of aminodienes with aminals. The reactions proceed efficiently under mild conditions and exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5- to 16-membered N-heterocycles bearing diverse frameworks and functional groups.