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Palladium-Catalyzed Direct Intermolecular Amination of Unactivated Methylene C(sp3)–H Bonds with Azodiformates via Bidentate-Chelation Assistance

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posted on 10.02.2017, 00:00 by He-Yuan Bai, Zhi-Gang Ma, Min Yi, Jun-Bing Lin, Shu-Yu Zhang
An efficient and convenient method enabling direct amination of unactivated methylene C­(sp3)–H bonds to form C–N bonds with azodiformates as amino source is described. This method highlights the emerging strategy of unactivated methylene as versatile functional groups in organic synthesis and provides a strategy to construct functionalized C–N bonds for the synthesis of complex molecules.

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