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Palladium-Catalyzed Asymmetric α‑Arylation of Alkylnitriles

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posted on 2016-12-07, 00:00 authored by Zhiwei Jiao, Kwok Wei Chee, Jianrong “Steve” Zhou
Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.