ol7b02704_si_005.cif (399.63 kB)

Palladium-Catalyzed [5 + 2] Cycloaddition of Vinyloxiranes with Sulfamate-Derived Cyclic Imines To Construct 1,3-Oxazepine Heterocycles

Download (399.63 kB)
posted on 18.11.2017, 20:29 by Yang Wu, Chunhao Yuan, Chang Wang, Biming Mao, Hao Jia, Xing Gao, Jianning Liao, Feng Jiang, Leijie Zhou, Qijun Wang, Hongchao Guo
Palladium-catalyzed [5 + 2] cycloaddition of 2-aryl-2-vinyloxiranes with sulfamate-derived cyclic imines is described. The zwitterionic allylpalladium intermediates act as five-membered synthon to react with sulfamate-derived cyclic imines to furnish [5 + 2] cycloaddition, giving 1,3-oxazepine derivatives in moderate to excellent yields with excellent regioselectivities.