Organocatalytic and Enantioselective Synthesis of β-(Hydroxyalkyl)-γ-Butyrolactones

Organocatalytic cross-aldol reaction of methyl 4-oxobutyrate (2) and a variety of aldehydes 3 followed by reduction with NaBH₄ has provided a one-pot, general and efficient method for the synthesis of 4-(hydroxyalkyl)-γ-butyrolactones 1 with high diastereo- (dr > 24:1) and enantioselectivity (ee > 99%).