ao8b02132_si_003.cif (985.28 kB)

Organocatalytic Enantioselective Mannich Reaction: Direct Access to Chiral β‑Amino Esters

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posted on 29.01.2019, 09:16 by G. Ravi Kumar, Boora Ramesh, Suresh Yarlagadda, Balasubramanian Sridhar, B. V. Subba Reddy
An asymmetric Mannich reaction has been developed to generate chiral β-amino esters in good yields with excellent enantiomeric excesses (ee, up to 99%) using a chiral bifunctional thiourea catalyst derived from (R,R)-cyclohexyldiamine. This is the first report on the addition of 3-indolinone-2-carboxylates to N-Boc-benzaldimines generated in situ from α-amidosulfones, which proceeds under mild conditions.