jo0623639_si_002.cif (11.31 kB)

Organocatalytic Cascade Reactions Based on Push−Pull Dienamine Platform:  Synthesis of Highly Substituted Anilines

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posted on 16.02.2007, 00:00 by Dhevalapally B. Ramachary, Kinthada Ramakumar, Vidadala V. Narayana
A practical and novel one-pot organocatalytic selective process for the cascade synthesis of highly substituted o-hydroxydiarylamines and o-pyrrolidin-1-yldiarylamines is reported. Direct combination of amine-catalyzed cascade Knoevenagel/Michael/aldol condensation/decarboxylation and cascade enamine amination/isoaromatization of alkyl acetoacetates, aldehydes, and nitrosoarenes furnished the highly functionalized anilines with high yields.