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Opaliferin, a New Polyketide from Cultures of Entomopathogenic Fungus Cordyceps sp. NBRC 106954

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posted on 19.09.2014, 00:00 by Aleksandra Grudniewska, Sayaka Hayashi, Mina Shimizu, Masayuki Kato, Midori Suenaga, Hiroshi Imagawa, Takuya Ito, Yoshinori Asakawa, Sayaka Ban, Toshio Kumada, Toshihiro Hashimoto, Akemi Umeyama
Opaliferin, a polyketide with a unique partial structure in which a cyclopentanone and tetrahydrofuran were connected with an external double bond, was isolated from the insect pathogenic fungus Cordyceps sp. NBRC 106954. The structure and relative configuration of opaliferin were determined by spectroscopic analysis and X-ray crystallography. The absolute configuration was established by anomalous dispersion effects in X-ray diffraction measurements on the crystal of di­(p-bromobenzoyl) ester of opaliferin. A plausible biosynthetic pathway for opaliferin is proposed.