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One-Step Synthesis of Saturated Spirocyclic N‑Heterocycles with Stannyl Amine Protocol (SnAP) Reagents and Ketones

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posted on 24.12.2014, 00:00 by Woon-Yew Siau, Jeffrey W. Bode
The combination of cyclic ketones and stannyl amine protocol (SnAP) reagents affords saturated, spirocyclic N-heterocycles under operationally simple reaction conditions. The resulting, N-unprotected spirocyclic amines are in great demand as scaffolds for drug discovery and development. The union of SnAP reagents and acyclic trifluoro­methyl­ketones yields α-CF3 morpholines and piperazines.