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One-Step Semisynthesis Method of Spirocurcasone and Pyracurcasone from Curcusones A and B

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posted on 18.04.2014, 00:00 authored by Xu-Yang Li, Yuan-Feng Yang, Xing-Rong Peng, Ming-Ming Li, Liang-Qun Li, Xu Deng, Hong-Bo Qin, Jie-Qing Liu, Ming-Hua Qiu
High contents of curcusones A and B and trace amounts of spiro­curcasone exist in the roots of Jatropha curcas. Here, a one-step semi­synthesis method of spiro­curca­sone and pyra­curca­sone was built, not only resulted an increased yield of spiro­curca­sone but also produced pyra­curca­sone, which exhibited greater cytotoxicity compared to curcusones A and B. The plausible mechanism of the formation of pyra­curca­sone was proposed, and the proposed biogenetic origin for spiro­curcasone by Taglialatela-Scafati was confirmed.