One-Pot Synthesis of Benzo[4,5]imidazo[2,1‑<i>a</i>]isoquinolines and Isoquinolino[3,4‑<i>b</i>]quinoxalines via Tandem Cyclization Strategies
dataset
posted on 2016-03-30, 00:00 authored by Alex L. Bagdasarian, Huy H. Nguyen, Teresa
A. Palazzo, James C. Fettinger, Makhluf J. Haddadin, Mark J. KurthTwo operationally
simple one-pot protocols have been developed
for the synthesis of amino-functionalized benzo[4,5]imidazo[2,1-<i>a</i>]isoquinolines and isoquinolino[3,4-<i>b</i>]quinoxalines.
Optimization data and substrate scope for these atom-economical transformations,
which engage commercially available <i>o</i>-phenylenediamines
and <i>o</i>-cyanobenzaldehydes, are discussed.
