jo0c02103_si_002.cif (2.09 MB)
One-Pot Synthesis of Enantiopure Pyrrolopiperazines
datasetposted on 2020-10-14, 20:43 authored by Pablo Pertejo, Beatriz González-Saiz, Roberto Quesada, María García-Valverde
A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.