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One-Pot Synthesis of Enantiopure Pyrrolopiperazines

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posted on 14.10.2020, 20:43 authored by Pablo Pertejo, Beatriz González-Saiz, Roberto Quesada, María García-Valverde
A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.