One-Pot Synthesis of Enantiopure Pyrrolopiperazines

Name: One-Pot Synthesis of Enantiopure Pyrrolopiperazines
Published: 2020-10-14T20:43:20+00:00
License: https://creativecommons.org/licenses/by-nc/4.0/
Keywords: pyrrolopiperazine, nonprotected diamines, one-pot protocol, Ugi reaction, enamine alkylation, synthesis, diastereoselectivity, Enantiopure Pyrrolopiperazines, arylglyoxal, multicomponent domino reaction, One-Pot Synthesis, novel methodology

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posted on 2020-10-14, 20:43 authored by Pablo Pertejo, Beatriz González-Saiz, Roberto Quesada, María García-Valverde

A simple one-pot protocol for the synthesis of fused pyrrolopiperazines with a complete diastereoselectivity has been developed. This novel methodology combined the Ugi reaction with a spontaneous enamine alkylation on a multicomponent domino reaction, starting from nonprotected diamines and arylglyoxals.

One-Pot Synthesis of Enantiopure Pyrrolopiperazines

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