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On the Reaction of 1-Oxa-4-thiaspiro[4.5]decan-7-one with PhLi. A Reinvestigation

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posted on 12.11.2004, 00:00 by Veejendra K. Yadav, Govindaraji Senthil, Latika Singh, Masood Parvez
Two diastereomeric alcohols are formed from the reaction of 1-oxa-4-thiaspiro[4.5]decan-7-one with PhLi as against the single diastereomer reported earlier. The diastereoselectivity achieved from PhMgBr is significantly higher than with PhLi. The use of Et2O/hexane = 2:1 as the solvent for the reaction with PhMgBr offered the highest (14:1) diastereocontrol.

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