American Chemical Society
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Oleanane-Type Triterpenoids from the Leaves and Twigs of Fatsia polycarpa

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posted on 2011-08-26, 00:00 authored by Shi-Yie Cheng, Chao-Min Wang, Yuan-Man Hsu, Tsurng-Juhn Huang, Shen-Chieh Chou, En-Hung Lin, Chang-Hung Chou
Seven new oleanane-type triterpenoids (17), named fatsicarpains A–G, and the known compounds 3α-hydroxyolean-11,13(18)-dien-28-oic acid (8) and 3α-hydroxyolean-11-en-28,13β-olide (9) were isolated from the leaves and twigs of Fatsia polycarpa on the basis of bioassay-guided fractionation. The structures of compounds 17 were elucidated through spectroscopic analyses and single-crystal X-ray crystallography of 1, 8, and 9. Cytotoxicity against HepG2 2.2.15 and AGS cells and antihepatitis B virus (HBV) and antibacterial activities of 19 were also evaluated in vitro.