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Octahedral Ruthenium Complex with Exclusive Metal-Centered Chirality for Highly Effective Asymmetric Catalysis

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posted on 14.03.2017, 00:00 authored by Yu Zheng, Yuqi Tan, Klaus Harms, Michael Marsch, Radostan Riedel, Lilu Zhang, Eric Meggers
A novel ruthenium catalyst is introduced which contains solely achiral ligands and acquires its chirality entirely from octahedral centro­chirality. The configurationally stable catalyst is demonstrated to catalyze the alkynyl­ation of trifluoro­methyl ketones with very high enantio­selectivity (up to >99% ee) at low catalyst loadings (down to 0.2 mol%).