American Chemical Society
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Novel, Short, Stereospecific Synthesis of lyxo-(2R,3R,4R)-Phytosphingosine and erythro-(2R,3S)-Sphingosine

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posted on 2003-08-14, 00:00 authored by Sadagopan Raghavan, A. Rajender
lyxo-Phytosphingosine and erythro-sphingosine have been elaborated from a common intermediate. The key step in the reaction sequence involves stereo- and regiospecific functionalization of an olefin by intramolecular nucleophilic sulfinyl group participation.