American Chemical Society
ja8b09677_si_002.cif (489.03 kB)

Nickel-Catalyzed Reductive [2+2] Cycloaddition of Alkynes

Download (489.03 kB)
posted on 2018-12-05, 00:00 authored by Santiago Cañellas, John Montgomery, Miquel À. Pericàs
The nickel-catalyzed synthesis of tetrasubstituted cyclobutenes from alkynes is reported. This transformation is uniquely promoted by the use of a primary aminophosphine, an unusual ligand in nickel catalysis. Mechanistic insights for this new transformation are provided, and postreaction modifications of the cyclobutene products to stereodefined cyclic and acyclic compounds are reported, including the synthesis of epi-truxillic acid.