American Chemical Society
ja6b04088_si_002.cif (758.34 kB)

Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2

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posted on 2016-06-07, 00:00 authored by Marino Börjesson, Toni Moragas, Ruben Martin
A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlorides with CO2 at atmospheric pressure is described. This protocol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.