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New Initiation Modes for Directed Carbonylative C–C Bond Activation: Rhodium-Catalyzed (3 + 1 + 2) Cycloadditions of Amino­methyl­cyclo­propanes

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posted on 06.10.2016, 19:07 authored by Gang-Wei Wang, Niall G. McCreanor, Megan H. Shaw, William G. Whittingham, John F. Bower
Under carbonylative conditions, neutral Rh­(I)-systems modified with weak donor ligands (AsPh3 or 1,4-oxathiane) undergo N-Cbz, N-benzoyl, or N-Ts directed insertion into the proximal C–C bond of amino­methyl­cyclo­propanes to generate rhodacyclo­pentanone intermediates. These are trapped by N-tethered alkenes to provide complex perhydroisoindoles.