American Chemical Society
np800632f_si_001.cif (13.48 kB)

Neopyrrolomycins with Broad Spectrum Antibacterial Activity

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posted on 2009-02-27, 00:00 authored by D. Craig Hopp, Joshua Rhea, Daniel Jacobsen, Khadidja Romari, Chris Smith, John Rabenstein, Macarena Irigoyen, Midori Clarke, Linda Francis, Michele Luche, Grant J. Carr, Ulla Mocek
Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 μg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).