Mutual Induced Fit in a Synthetic Host–Guest System
datasetposted on 26.03.2014, 00:00 by Tomohisa Sawada, Hayato Hisada, Makoto Fujita
Mutual induced fit is an important phenomenon in biological molecular recognition, but it is still rare in artificial systems. Here we report an artificial host–guest system in which a flexible calixarene is enclathrated in a dynamic self-assembled host and both molecules mutually adopt specific three-dimensional structures. NMR data revealed the conformational changes, and crystallographic studies clearly established the precise structures at each stage.