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Download fileMutual Induced Fit in a Synthetic Host–Guest System
dataset
posted on 26.03.2014, 00:00 authored by Tomohisa Sawada, Hayato Hisada, Makoto FujitaMutual
induced fit is an important phenomenon in biological molecular
recognition, but it is still rare in artificial systems. Here we report
an artificial host–guest system in which a flexible calix[4]arene
is enclathrated in a dynamic self-assembled host and both molecules
mutually adopt specific three-dimensional structures. NMR data revealed
the conformational changes, and crystallographic studies clearly established
the precise structures at each stage.