American Chemical Society
co6b00003_si_004.cif (4.34 MB)

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4‑b]quinoline Hybrid Heterocycles

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posted on 2016-03-30, 00:00 authored by Remani Vasudevan Sumesh, Muthumani Muthu, Abdulrahman I. Almansour, Raju Suresh Kumar, Natarajan Arumugam, S. Athimoolam, E. Arockia Jeya Yasmi Prabha, Raju Ranjith Kumar
The stereoselective syntheses of a library of novel spiro-tethered pyrazolo­[3,4-b]­quinoline–pyrrolidine/pyrrolothiazole/indolizine–oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo­[3,4-b]­quinoline derivatives.