ol502656g_si_002.cif (16.28 kB)

Multicomponent Cascade Cycloaddition Involving Tropone, Allenoate, and Isocyanide: A Rapid Access to a 7,6,5-Fused Tricyclic Skeleton

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posted on 07.11.2014, 00:00 by Shuanglong Jia, Shikuan Su, Chunju Li, Xueshun Jia, Jian Li
Multicomponent cascade cycloaddition of tropone, allenoate, and isocyanide has been disclosed. This method allows for the rapid construction of a highly unusual tricyclic skeleton in an efficient manner. The proposed transformation proceeds through [8 + 2 + 1] cycloaddition, [1,5]-H shift, and cyclization followed by an alkoxy group migration process.