Multicomponent 1,3-Bifunctionalization of Donor–Acceptor Cyclopropanes with Arenes and Nitrosoarenes
datasetposted on 19.10.2016 by Saikat Das, Constantin G. Daniliuc, Armido Studer
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AlBr3-mediated multicomponent 1,3-bifunctionalization of donor–acceptor cyclopropanes using arenes and nitrosoarenes as coupling partners is presented. In the cascade, a C–C, a C–N, and a C–Br bond is formed. Reactions are easy to conduct and proceed under mild conditions. The γ,γ-disubstituted N-arylated α-amino esters obtained as products are readily further chemically modified rendering the method valuable.