np8b00863_si_002.cif (880.5 kB)
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum
dataset
posted on 2019-02-06, 20:44 authored by Pan Luo, Yanfang Cheng, Zhiyong Yin, Chanjuan Li, Jun Xu, Qiong GuTwelve new guaianolide-type sesquiterpenoids
(1–12) and five known guaianolide
derivatives (13–17) were isolated
from an aqueous ethanol extract
of the aerial parts of Chrysanthemum indicum. Their
structures were determined through spectroscopic data analysis. The
absolute configurations of the new compounds were assigned by X-ray
crystallography and electronic circular dichroism. Compound 5 shows multiple cytotoxic activities against four human naso-pharyngeal
carcinoma (NPC) cell lines (CNE1, CNE2, SUNE-1, and HONE-1) and one
human intestinal epithelial cell line (HT-29) with IC50 values of 4.6, 6.0, 3.5, 4.3, and 9.6 μM, respectively. Compound 16 exhibits weak cytotoxicity against four NPC cell lines,
CNE1 (IC50 = 7.3 μM), CNE2 (IC50 = 7.4
μM), HONE-1 (IC50 = 7.6 μM), and SUNE-1 (IC50 = 5.6 μM), but no cytotoxicity against HT-29 (IC50 > 10 μM).