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Metal-Free Synthesis of Indole via NIS-Mediated Cascade C–N Bond Formation/Aromatization

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posted on 17.04.2015, 00:00 by Yin-Long Li, Jian Li, Ai-Lun Ma, Ya-Nan Huang, Jun Deng
A novel rapid synthesis of indoles from N-Ts-2-alkenylanilines has been described; the reaction involves a NIS-mediated cascade C–N bond formation/aromatization, and a series of indoles with various functional groups have been synthesized in good to excellent yields under mild conditions without any other additives or catalysts.