Metal-Free Synthesis of 2‑Oxindoles via PhI(OAc)<sub>2</sub>‑Mediated Oxidative C–C Bond Formation
dataset
posted on 2014-02-07, 00:00 authored by Jinglei Lv, Daisy Zhang-Negrerie, Jun Deng, Yunfei Du, Kang ZhaoThe
series of 3-monofunctionalized 2-oxindoles <b>2</b> were conveniently
synthesized from reactions between anilide <b>1</b> and phenyliodine(III)
diacetate (PIDA) through hypervalent iodine mediated C(sp<sup>2</sup>)–C(sp<sup>2</sup>) bond formation followed by a subsequent
deacylation reaction. This metal-free method, shown to provide direct
access to an important oxindole intermediate, could be applied to
the total synthesis of naturally occurring horsfiline.
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- 1. DOI - Is supplement to Metal-Free Synthesis of 2‑Oxindoles via PhI(OAc)2‑Mediated Oxidative C–C Bond Formation
