jo8b00676_si_002.cif (314.6 kB)

Metal-Free Electrophilic Trifluoroethylthiolation with NaSO2CH2CF3

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posted on 02.07.2018, 00:00 by Rongkang Wang, Lvqi Jiang, Wenbin Yi
Metal-free trifluoroethylthiolation with fluorinated sulfinate salt NaSO2CH2CF3 under reductive conditions has been developed. The strategy enables the installation of the SCH2CF3 moiety efficiently to form a number of unexplored stable trifluoroethylthiolated heterocycles, arenes, and thiols, which have the potential to be a new series of fluorine-containing chemical entities for medicinal chemists.