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Metal-Free Aminothiation of Alkynes: Three-Component Tandem Annulation toward Indolizine Thiones from 2‑Alkylpyridines, Ynals, and Elemental Sulfur

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posted on 2019-09-26, 03:13 authored by Zhengwang Chen, Pei Liang, Fan Xu, Zhen Deng, Lipeng Long, Guotian Luo, Min Ye
A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C–C/C–N/C–S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.

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