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Maximumins A–D, Rearranged Labdane-Type Diterpenoids with Four Different Carbon Skeletons from Amomum maximum

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posted on 09.12.2018, 00:00 by Kai-Long Ji, Yao-Yue Fan, Zhan-Peng Ge, Li Sheng, You-Kai Xu, Li-She Gan, Jing-Ya Li, Jian-Min Yue
Four highly rearranged labdane-type diterpenoids, maximumins A–D (14) possessing different new carbon skeletons, together with a biosynthetically related known analog 5 were isolated from Amomum maximum. The structures of new compounds with absolute configurations were characterized by spectroscopic and computational approaches. The plausible biogenetic pathways for 14 were proposed. These compounds showed moderate to weak activities against nuclear factor kappa B (NF-κB).