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Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta

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posted on 02.03.2016, 19:35 by Guo-Cai Wang, Jin-Hai Yu, Yu Shen, Ying Leng, Hua Zhang, Jian-Min Yue
Nine new cedrelone-type limonoid derivatives, walsunoids A–I (19), and 11 known compounds were isolated from the leaves of Walsura robusta. Walsunoid A (1) is a new degradation product of cedrelone-type limonoids, and walsunoid I (9) is a rare cedrelone-type limonoid amide. Their structures and absolute configurations were determined by spectroscopic data, single-crystal X-ray diffraction, and ECD data analyses. Five compounds showed moderate inhibitory activities against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) with IC50 values ranging from 0.69 to 9.9 μM.