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Lewis Acid Catalyzed Formation of Tetrahydroquinolines via an Intramolecular Redox Process

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posted on 01.01.2009, 00:00 by Sandip Murarka, Chen Zhang, Marlena D. Konieczynska, Daniel Seidel
Polycyclic tetrahydroquinolines were prepared by an efficient Lewis acid catalyzed 1,5-hydride shift, ring closure sequence. Gadolinium triflate was identified as a catalyst that is superior to scandium triflate as well as other Lewis acids. An approach toward a catalytic enantioselective variant is also described.