posted on 2019-01-28, 00:00authored byYe Wang, Wen-Yun Zhang, Shu-Li You
Ketones and aldehydes
are employed as enol O-nucleophiles
in an iridium-catalyzed asymmetric allylic substitution reaction.
The reaction proceeds well in the presence of a well-defined chiral
iridium complex under mild conditions. A series of chiral 2H-1,4-oxazine skeletons can be obtained in up to 94% yield
with 99% ee. The utility of this novel method has been demonstrated
by its implementation in the first enantioselective synthesis of (+)-chelonin
A.