ja6b08958_si_002.cif (1.07 MB)
Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield
datasetposted on 2016-10-04, 00:00 authored by James E. M. Lewis, Joby Winn, Luca Cera, Stephen M. Goldup
We present an operationally simple iterative coupling strategy for the synthesis of oligomeric homo- and hetero[n]rotaxanes with precise control over the position of each macrocycle. The exceptional yield of the AT-CuAAC reaction, combined with optimized conditions that allow the rapid synthesis of the target oligomers, opens the door to the study of precision-engineered oligomeric interlocked molecules.