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Isolation and Structure of Providencin:  A Highly Oxygenated Diterpene Possessing a Unique Bicyclo[12.2.0]hexadecane Ring System from the Sea Plume Pseudopterogorgia kallos

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posted on 07.06.2003, 00:00 by Jeffrey Marrero, Abimael D. Rodríguez, Peter Baran, Raphael G. Raptis
Providencin (1) is a naturally occurring cytotoxin isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed bicyclo[12.2.0]hexadecane ring system and was established through spectroscopic analysis and X-ray crystallographic analysis. Providencin (1) was shown to exhibit modest anticancer activity against human breast (MCF7), lung (NCI-H460), and CNS (SF-268) cancer cell lines.