Isolation, Structure Elucidation, and Absolute Configuration of Highly Oxygenated Germacranolides from Carpesium cernuum
dataset
posted on 2016-09-26, 16:06 authored by Qing-Xin Liu, Yong-Xun Yang, Jian-Ping Zhang, Li-Ping Chen, Yun-Heng Shen, Hui-Liang Li, Wei-Dong ZhangThe new highly oxygenated germacranolides
cernuumolides A–J (1–10) and
the known compounds 11–20 were isolated
from Carpesium cernuum. Among these compounds, 1–4 are 11-methoxymethylgermacranolides
and 5–7 as well as 11–17 are 2,9-hemiacetal-linked germacranolides.
Their structures were elucidated using NMR and HRESIMS analyses, and
X-ray diffraction studies were used to confirm the absolute configurations
of 1, 2, 5, 6, 8, and 9. Cernuumolides A–J were evaluated
for their in vitro cytotoxicity against the A549, HCT116, MDA-MB-231,
and BEL7404 cell lines, and 8 exhibited moderate cytotoxicity
with IC50 values in the 0.87–2.02 μM range.
