ja310203c_si_003.cif (39.6 kB)

Iron-Catalyzed Dioxygen-Driven C–C Bond Formation: Oxidative Dearomatization of 2‑Naphthols with Construction of a Chiral Quaternary Stereocenter

Download (39.6 kB)
posted on 20.02.2016, 04:01 by Takuya Oguma, Tsutomu Katsuki
Iron­(salan) complex 1 was found to catalyze the oxidative dearomatization of 1-substituted 2-naphthols with the formation of an all-carbon quaternary stereocenter in air in the presence of nitroalkanes, to afford the corresponding cyclic enones with high enantioselectivity of 88–96% ee.